Post-mortem perinatal imaging: what is the evidence?

Area of Science:

• Medical Imaging
• Pathology
• Perinatal Medicine

Background:

• Post-mortem imaging is an acceptable, less invasive alternative to traditional autopsy for perinatal deaths.
• Limited availability and lack of standardized protocols hinder widespread adoption.
• Existing literature often comprises single-center studies or case reports.

Purpose of the Study:

• To provide a comprehensive review of post-mortem imaging research and guidelines for perinatal death investigation.
• To guide the selection of appropriate imaging modalities based on specific indications.
• To outline considerations for invasive autopsy when imaging findings are discordant with clinical data.

Main Methods:

• Review of current literature on diagnostic accuracy of various post-mortem imaging modalities (CT, MRI, ultrasound, micro-CT).
• Synthesis of recently published international guidelines on perinatal post-mortem imaging.
• Description of modality-specific applications and indications.

Main Results:

• Post-mortem imaging is a valuable tool, with diagnostic accuracy varying by modality and indication.
• A multidisciplinary team approach is crucial for successful implementation and interpretation.
• Guidelines exist, but consensus on optimal protocols requires further development.

Conclusions:

• Post-mortem imaging is a viable and accepted method for investigating perinatal deaths.
• Selecting the right imaging modality and fostering multidisciplinary collaboration are key to service success.
• Further research and standardization are needed to address current limitations.