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Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia

Goutham Narayanan Subramanian1, Abrey Jie Yeo1, Magtouf Hnaidi Gatei1

  • 1University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia.

Antioxidants (Basel, Switzerland)
|April 23, 2022
PubMed

Insights

The ataxia-telangiectasia mutated (ATM) protein kinase protects cells from DNA damage and other stresses. This review explores ATM

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • Ataxia-telangiectasia mutated (ATM) protein kinase is crucial for cellular homeostasis.
  • Mutations in ATM cause the human genetic disorder ataxia-telangiectasia (A-T).
  • ATM plays a significant role in cell signaling pathways.

Purpose of the Study:

  • To review the broader role of ATM in cellular protection beyond DNA damage.
  • To explore ATM's function in response to oxidative and non-DNA damaging stress.
  • To highlight ATM's protective functions in both the nucleus and cytoplasm.

Main Methods:

  • Literature review of ATM's functions.
  • Analysis of ATM's involvement in various cellular stress responses.
  • Examination of ATM localization within the cell (nucleus and cytoplasm).

Main Results:

  • ATM is essential for protecting cells against DNA damage.
  • ATM also maintains cell homeostasis under oxidative and other stresses.
  • ATM's presence in the cytoplasm suggests a wider protective role.

Conclusions:

  • ATM has a multifaceted role in cellular protection against diverse stresses.
  • Understanding ATM's broader functions is key to comprehending cellular resilience.
  • Further research into ATM's cytoplasmic functions is warranted.
Keywords:
anaplerosisataxia-telangiectasiaataxia-telangiectasia mutated protein kinasemetabolic stressmitochondrial dysfunction

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