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Related Experiment Videos

Complement-fixing pemphigus antibodies.

T Hashimoto, T Nishikawa, S Kurihara

    Archives of Dermatology
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Complement-fixing pemphigus antibodies in serum correlate with active pemphigus vulgaris. These antibodies and complement C3 binding suggest the complement system

    Area of Science:

    • Immunodermatology
    • Autoimmunity
    • Complement System

    Background:

    • Pemphigus vulgaris is an autoimmune blistering disease characterized by autoantibodies targeting intercellular components of the epidermis.
    • The role of the complement system in the pathogenesis of pemphigus vulgaris remains incompletely understood.

    Observation:

    • Serum from patients with active pemphigus vulgaris contains complement-fixing intercellular autoantibodies (pemphigus antibodies).
    • These complement-fixing pemphigus antibodies were detected only during untreated active disease stages.
    • Pemphigus lesional skin demonstrated in-vivo-bound IgG capable of further binding C3 in vitro.

    Findings:

    • Complement-fixing pemphigus antibodies were present at lower titers than corresponding IgG autoantibodies.

    Related Experiment Videos

  • The levels of complement-fixing pemphigus antibodies paralleled disease activity.
  • The complement system component C3 was found to bind to pemphigus lesional skin.

    • Implications:

    • The complement system may actively contribute to acantholysis in pemphigus vulgaris.
    • Complement-fixing pemphigus antibodies are implicated in the disease mechanism.
    • Further research into complement activation pathways in pemphigus is warranted.