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Plg-R<sub>KT</sub> facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice.

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Plg-RKT Expression in Human Breast Cancer Tissues.

Lindsey A Miles1, Stan Krajewski2, Nagyung Baik1

  • 1Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.

Biomolecules
|April 23, 2022
PubMed
Summary
This summary is machine-generated.

Plasminogen Receptor KT (Plg-RKT) is widely expressed in breast tumors and increases with cancer spread. Its expression is highest in aggressive, hormone receptor-positive tumors, suggesting a role in breast cancer progression.

Keywords:
Plg-RKTbreast cancerplasminogentissue microarraystumor microenvironment

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The plasminogen activation system regulates plasmin activity, crucial for tissue remodeling.
  • Plasminogen receptors modulate the tumor microenvironment and are key in cancer progression.
  • Plg-RKT is a unique integral membrane plasminogen receptor binding via a C-terminal lysine.

Purpose of the Study:

  • To investigate the expression of Plg-RKT in human breast tumors and cell lines.
  • To correlate Plg-RKT expression with breast cancer progression and characteristics.

Main Methods:

  • Tissue microarrays of breast cancer progression were probed with anti-Plg-RKT monoclonal antibodies.
  • Western blotting was used to detect Plg-RKT in breast cancer cell lines.
  • Flow cytometry assessed Plg-RKT cell surface expression on aggressive tumor cell lines.

Main Results:

  • Plg-RKT is widely expressed in human breast tumors.
  • Increased Plg-RKT expression correlates with tumor spread to lymph nodes and distant organs.
  • Plg-RKT expression is most pronounced in hormone receptor-positive tumors and highest on aggressive cell lines.

Conclusions:

  • Plg-RKT is broadly expressed in breast tumors and its expression correlates with advanced disease.
  • Plg-RKT may play a significant role in breast cancer progression, particularly in hormone receptor-positive subtypes.
  • Further research into Plg-RKT functions in breast cancer is warranted.