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Related Experiment Video

Updated: Sep 26, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
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Brain Metastases from Gynecologic Malignancies.

Georgia Karpathiou1, Florian Camy1, Céline Chauleur2

  • 1Pathology Department, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France.

Medicina (Kaunas, Lithuania)
|April 23, 2022
PubMed
Summary

Brain metastases from gynecologic cancers, particularly ovarian and endometrial, were analyzed. Better performance status and smaller metastasis size indicate a good prognosis for these patients.

Keywords:
brain metastasisendometrial cancerovarian cancer

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Area of Science:

  • Gynecologic Oncology
  • Neurology
  • Oncology

Background:

  • Brain metastases are a significant complication of gynecologic cancers.
  • Understanding the characteristics and prognosis of brain metastases is crucial for patient care.

Purpose of the Study:

  • To present a series of brain metastases originating from gynecologic primary tumors.
  • To summarize the existing literature on this topic.

Main Methods:

  • Retrospective review of 18 patients with histologically confirmed brain metastases from gynecologic primaries.
  • Comprehensive literature review and synthesis of reported cases.

Main Results:

  • The series included 6 endometrial and 12 ovarian primary brain metastases.
  • Median survival after diagnosis was 5 months, with better performance status and smaller metastasis size as favorable prognostic factors.
  • Endometrial cancer brain metastases were diagnosed earlier than ovarian cancer brain metastases.

Conclusions:

  • Performance status and smaller brain metastasis size are significant prognostic indicators.
  • Brain metastases from endometrial cancer tend to develop earlier compared to those from ovarian cancer.