Primary Intraosseous Osteolytic Meningioma with Aggressive Clinical Behaviour: Clinico-Pathologic Correlation and...

Area of Science:

• Neurosurgery
• Oncology
• Pathology

Background:

• Primary intraosseous osteolytic meningiomas (PIOM) are a subset of primary extradural meningiomas (PEM).
• These tumors are characterized by an osteolytic component, sometimes with hyperostotic reactions, and are not dural-based.
• Previous classification systems have limitations, necessitating a new approach.

Purpose of the Study:

• To present a unique case of PIOM.
• To conduct a systematic literature review of PIOM cases.
• To propose a novel classification system for PIOM.

Main Methods:

• Systematic literature search of Google Scholar, PubMed, and Scopus databases up to December 2020.
• Inclusion of case studies on PIOM, adhering to PRISMA guidelines.
• Analysis of a new case of PIOM in a 46-year-old female patient.

Main Results:

• A total of 55 PIOM cases (including the presented case) were analyzed.
• The most common location was the frontal and parietal calvarium (29.1% frontal bone).
• Surgical resection (87.3%) with Gross Total Resection (GTR) achieved in 80% of cases was the primary treatment, with low recurrence rates (7.3%).

Conclusions:

• Surgical resection, especially GTR, is the treatment of choice for PIOM.
• PIOMs have a high GTR rate and low risk of complications and mortality.
• Further research is needed for differential diagnosis and specific PIOM treatments.