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An Updated Overview of MRI Injuries in Neonatal Encephalopathy: LyTONEPAL Cohort
Jonathan Beck1,2, Gauthier Loron1,3, Pierre-Yves Ancel2,4
1Department of Neonatology, Reims University Hospital Alix de Champagne, 51100 Reims, France.
Children (Basel, Switzerland)
|April 23, 2022
Summary
Brain injuries are common in newborns with hypoxic-ischemic encephalopathy (HIE). Basal ganglia, white matter, and cortex are most affected, with early MRI revealing more severe injuries.
Area of Science:
- Neonatal neurology
- Neuroimaging
- Pediatric radiology
Background:
- Brain magnetic resonance imaging (MRI) is crucial for prognosing newborns affected by hypoxic-ischemic events.
- Characterizing brain injuries in neonates with hypoxic-ischemic encephalopathy (HIE) is essential for understanding outcomes.
Purpose of the Study:
- To precisely characterize the patterns of brain injuries in newborns with HIE using MRI.
- To identify the predominant locations and potential timing of these brain injuries.
Main Methods:
- Descriptive analysis of brain MRIs from the French national, multicentric LyTONEPAL cohort.
- Inclusion criteria: infants with grade II or III encephalopathy and gestational age ≥36 weeks, with MRI performed before 12 days of life.
Main Results:
- 52.4% of included infants (n=520) showed brain injury.
- Predominant injury sites included basal ganglia (33.8%), white matter (33.5%), and cortex (25.6%).
- Early MRIs (before 6 days) showed more frequent basal ganglia, internal capsule, brainstem, and cortical injuries compared to later MRIs.
Conclusions:
- This study provides an overview of brain injury patterns in neonatal hypoxic-ischemic encephalopathy.
- Basal ganglia (with thalamus) and white matter (periventricular) were the most common injury locations.
- Detailed identification of brain injuries aids in understanding HIE mechanisms and injury timing.
