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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Updated: Sep 26, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Epigenetics in Precision Nutrition.

Xiang Li1, Lu Qi1,2

  • 1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

Journal of Personalized Medicine
|April 23, 2022
PubMed
Summary
This summary is machine-generated.

Precision nutrition research explores individual responses to diet, focusing on epigenetics like DNA methylation. Epigenetic factors offer promising targets for personalized nutrition interventions and disease management.

Keywords:
CVDDNA methylationepigenomicsobesityprecision nutritiontype 2 diabetes

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Area of Science:

  • Nutritional Science
  • Genetics
  • Epigenetics

Background:

  • Precision nutrition investigates individual variability in response to diet and lifestyle.
  • Current research emphasizes genome and gut microbiome, largely neglecting the epigenome.
  • The epigenome interfaces between the genome and environmental factors like diet.

Purpose of the Study:

  • To review recent studies on DNA methylation in relation to obesity, diabetes, and cardiovascular disease.
  • To highlight the role of DNA methylation in nutrition and diet/lifestyle interventions.
  • To discuss the potential of epigenetics, including non-coding RNAs, in precision nutrition.

Main Methods:

  • Literature review of recent studies.
  • Focus on DNA methylation, non-coding RNAs, and histone modification.
  • Analysis of epigenetic modifications' impact on metabolic health and dietary responses.

Main Results:

  • Epigenetic modifications, especially DNA methylation, significantly influence individual metabolic health.
  • DNA methylation is linked to obesity, diabetes, and cardiovascular disease.
  • Epigenetics shows promise for novel biomarkers and therapeutic targets in precision nutrition.

Conclusions:

  • Epigenetics, particularly DNA methylation, plays a crucial role in individual responses to nutrition and lifestyle.
  • Further research into epigenetics is essential for advancing precision nutrition and developing targeted interventions.
  • Epigenetic markers may lead to personalized dietary recommendations and disease prevention strategies.