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Emerging Evidence of Noncoding RNAs in Bleb Scarring after Glaucoma Filtration Surgery
Sabrina Yu1, Alex L C Tam2, Robert Campbell2
1Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Cells
|April 23, 2022
Summary
Noncoding RNAs, including microRNAs and long noncoding RNAs, show potential in preventing fibrosis after glaucoma surgery. Some RNAs have anti-fibrotic effects, while others may promote it, offering therapeutic targets.
Area of Science:
- Ophthalmology
- Molecular Biology
- Genetics
Background:
- Glaucoma filtration surgery can lead to fibrosis, potentially impairing surgical success.
- Noncoding RNAs (ncRNAs) are increasingly recognized for their roles in cellular processes, including fibrosis.
Purpose of the Study:
- To review research on the anti- and pro-fibrotic mechanisms of noncoding RNAs after glaucoma filtration surgery.
- To identify specific noncoding RNAs involved in post-surgical fibrosis.
Main Methods:
- A narrative review of research articles was conducted.
- Searches of PubMed and Medline databases were performed for relevant studies.
- Manual searches of reference lists were also utilized.
Main Results:
- Fifteen primary research articles were identified and reviewed.
- Several microRNAs (miRNAs) like miR-26a, -29b, -139, -155, and -200a demonstrated anti-fibrotic effects.
- Other miRNAs (miR-200b, -216b) and long noncoding RNAs (lncRNAs) such as H19, NR003923, and 00028 showed pro-fibrotic roles.
Conclusions:
- Noncoding RNAs, encompassing miRNAs and lncRNAs, represent promising therapeutic targets.
- Targeting specific noncoding RNAs could help prevent fibrosis following glaucoma filtration surgery.
