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Acute Kidney Injury Recovery Patterns in ST-Segment Elevation Myocardial Infarction Patients

Tamar Itach1, Ariel Banai1, Yael Paran2

  • 1Departments of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6423906, Israel.

Journal of Clinical Medicine
|April 23, 2022
PubMed

Insights

Acute kidney injury (AKI) recovery patterns in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) significantly impact outcomes. Patients with delayed or no AKI recovery face higher mortality risks.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Medicine

Background:

  • Acute kidney injury (AKI) is a common complication in ST-segment elevation myocardial infarction (STEMI) patients treated with percutaneous coronary intervention (PCI).
  • AKI recovery patterns are crucial for accurate patient prognostic stratification.
  • Understanding these patterns can guide clinical management and improve patient outcomes.

Purpose of the Study:

  • To investigate the clinical significance of different AKI recovery patterns in STEMI patients undergoing PCI.
  • To assess the association between AKI recovery status and in-hospital complications, as well as short and long-term mortality.

Main Methods:

  • Retrospective analysis of 2943 STEMI patients who underwent PCI.
  • Classification of patients into three groups: no AKI, early AKI recovery (creatinine normalization within 72 hours), and no/delayed AKI recovery.
  • Comparison of in-hospital complications and mortality rates across the defined groups.

Main Results:

  • 8.7% of STEMI patients developed AKI, with 49% experiencing early recovery and 51% having no/delayed recovery.
  • Patients with no/delayed AKI recovery exhibited significantly higher rates of in-hospital complications and long-term mortality (36.64% vs. 7.25%).
  • Multivariable regression confirmed no/delayed AKI recovery as a significant independent predictor of long-term mortality (HR 7.76).

Conclusions:

  • AKI recovery patterns serve as a valuable prognostic marker in STEMI patients undergoing PCI.
  • Early identification and management of AKI recovery are essential for improving patient prognosis.
  • Further research into interventions promoting AKI recovery in this population is warranted.

Keywords:
ST-segment elevation myocardial infarctionacute kidney injurycardiac intensive care unitpercutaneous coronary intervention

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