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Solid Dispersion Formulations by FDM 3D Printing-A Review.

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  • 1Department of Pharmaceutics and Pharmaceutical Technology, Bayero University, Kano P.M.B. 3011, Nigeria.

Pharmaceutics
|April 23, 2022
PubMed
Summary
This summary is machine-generated.

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Additive manufacturing (AM), specifically fused deposition modeling (FDM) 3D printing combined with solid dispersion, offers personalized medicine. This approach enhances drug solubility and bioavailability, addressing limitations of traditional mass production for specific patient groups.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Biomedical Engineering

Background:

  • Conventional drug manufacturing (fit-for-all) has significant limitations, especially for pediatric, elderly, and special needs patients, with less than 50% treatment efficacy.
  • Additive Manufacturing (AM) presents a paradigm shift towards fit-for-purpose medicine production, enabling on-demand and personalized dosage forms.

Purpose of the Study:

  • To review current trends in AM for personalized medicine, focusing on the synergy between solid dispersion and Fused Deposition Modeling (FDM) 3D printing.
  • To highlight the potential of combining these technologies to improve the therapeutic outcomes of poorly soluble drugs.

Main Methods:

  • Review of current literature on additive manufacturing techniques in pharmaceutical applications.
Keywords:
3D printing4D printingadditive manufacturingfused deposition modelingpersonalized therapypoorly soluble drugsprecision medicinesolid dispersion

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  • Focus on the integration of solid dispersion strategies with FDM 3D printing for drug delivery.
  • Analysis of advantages, challenges, and future directions.

    • Main Results:

    • Combining solid dispersion with FDM 3D printing can improve solubility, dissolution, and oral bioavailability of poorly soluble drugs (Class II/IV).
    • This approach supports precision medicine and personalized dosing, overcoming commercial limitations of drug-loaded filaments.
    • Key challenges include thermal degradation of sensitive drugs, and regulatory/ethical considerations for quality control and assurance.

    Conclusions:

    • The integration of solid dispersion and FDM 3D printing holds significant promise for personalized medicine and on-demand drug manufacturing.
    • Addressing thermal stability, regulatory compliance, and quality assurance is crucial for widespread adoption.
    • Collaborative efforts among stakeholders are essential to overcome existing challenges and realize the full potential of this technology.