Particle Engineering by Nano Spray Drying: Optimization of Process Parameters with Hydroethanolic versus Aqueous...

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Chemical Engineering

Background:

• Nano spray drying is a versatile method for producing micro- and nanoparticles.
• Its application in drug delivery is expanding, but process parameters require further elucidation.
• Understanding critical determinants is essential for consistent product quality.

Purpose of the Study:

• To comprehensively understand critical determinants of product characteristics in nano spray drying.
• To investigate the influence of process parameters on yield, moisture content, and particle size.
• To provide guidance for optimizing particle engineering for pulmonary drug delivery.

Main Methods:

• Employed a quality-by-design approach and factorial experimental design.
• Conducted spray drying experiments using the Büchi Nano Spray Dryer B-90.
• Investigated inlet temperature, spray solvent (aqueous vs. hydroethanolic), and solute concentration.

Main Results:

• Yields for lactose and mannitol were approximately 71.1% and 66.1%, respectively.
• Number-weighted median particle diameter was 1.6 μm, and volume-weighted median was 5.1 μm.
• Spray generation impacts yield; mesh pore size and solution saturation determine particle size.

Conclusions:

• Optimization of spray generation is crucial for maximizing yield in nano spray drying.
• Particle size is governed by spray mesh pore size and solution saturation.
• Solvent choice and solute concentration are key for optimizing spray flow and saturation for particle engineering.