Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Area of Science:

• Gerontology
• Cell Biology
• Molecular Biology

Background:

• Cellular senescence is a state of stable cell cycle arrest with implications for aging and disease.
• Senescence is induced by various factors and linked to age-related pathologies, DNA damage, and tissue repair.
• Contradictory findings exist regarding senescence triggers, biomarkers, and detection methods.

Purpose of the Study:

• To summarize recent findings on cellular senescence.
• To present common cellular and animal models used in senescence research.
• To briefly describe established senolytic agents.

Main Methods:

• Literature review of recent senescence research.
• Compilation of widely used cellular and animal senescence models.
• Summary of key senolytic drugs and their mechanisms.

Main Results:

• Senescence is a complex process with diverse inducers and roles in tissue homeostasis.
• Varied experimental models contribute to inconsistencies in senescence research.
• Senolytic agents offer potential therapeutic strategies for senescence-related conditions.

Conclusions:

• Clarifying senescence mechanisms and utilizing standardized models are crucial for advancing research.
• Senolytics represent a promising therapeutic avenue for age-related diseases.
• Further research is needed to reconcile existing data and refine detection protocols.