The Interplay between Hydrogen Sulfide and Phytohormone Signaling Pathways under Challenging Environments

Hydrogen sulfide (H₂S) serves as an important gaseous signaling molecule that is involved in intra- and intercellular signal transduction in plant-environment interactions. In plants, H₂S is formed in sulfate/cysteine reduction pathways. The activation of endogenous H₂S and its exogenous application has been found to be highly effective in ameliorating a wide variety of stress conditions in plants. The H₂S interferes with the cellular redox regulatory network and prevents the degradation of proteins from oxidative stress via post-translational modifications (PTMs). H₂S-mediated persulfidation allows the rapid response of proteins in signaling networks to environmental stimuli. In addition, regulatory crosstalk of H₂S with other gaseous signals and plant growth regulators enable the activation of multiple signaling cascades that drive cellular adaptation. In this review, we summarize and discuss the current understanding of the molecular mechanisms of H₂S-induced cellular adjustments and the interactions between H₂S and various signaling pathways in plants, emphasizing the recent progress in our understanding of the effects of H₂S on the PTMs of proteins. We also discuss future directions that would advance our understanding of H₂S interactions to ultimately mitigate the impacts of environmental stresses in the plants.