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Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas
Jordan A Higgs1, Alyssa P Quinn1, Kevin D Seely1
1College of Osteopathic Medicine, Rocky Vista University, Ivins, UT 84738, USA.
International Journal of Molecular Sciences
|April 23, 2022
Summary
Insulin resistance is linked to adrenal incidentalomas, but the exact cause is unclear. This review explores how adrenal masses and insulin resistance may influence each other, aiding future prevention and treatment.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Oncology
Background:
- Adrenal incidentalomas are common adrenal masses.
- A link exists between insulin resistance and adrenal incidentalomas.
- The pathophysiology of this association is not fully understood.
Purpose of the Study:
- To review the literature on the interrelationship between insulin resistance and adrenal masses.
- To explore the pathophysiology linking these two conditions.
Main Methods:
- Literature review of studies examining insulin resistance and adrenal masses.
- Analysis of potential pathophysiological mechanisms.
Main Results:
- Evidence suggests both adrenal masses causing insulin resistance and vice versa.
- Insulin resistance, hyperinsulinemia, and growth factor effects are potential links.
- Autonomous cortisol secretion from adrenal masses can cause insulin resistance.
Conclusions:
- The precise relationship and timing between insulin resistance and adrenal incidentalomas require further investigation.
- Understanding these mechanisms is crucial for prevention, detection, and treatment.
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