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Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Assessment of the Mouth

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.

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Exploring the Interplay Between Fatigue and the Oral Microbiome: A Longitudinal Approach.

Laura Presutti¹, Madison C Gueningsman¹, Blake Fredericksen²

¹Rocky Vista University College of Osteopathic Medicine, Englewood, CO 80112, USA.

|December 31, 2025

Summary

This summary is machine-generated.

Medical student fatigue is linked to changes in oral microbiome diversity. This study suggests microbial shifts may reflect adaptation to the stressful medical school environment, potentially impacting well-being.

Keywords:

fatigue and performance microbial diversity oral microbiome preclinical education

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Area of Science:

Microbiology
Medical Education
Human Physiology

Background:

Fatigue is a significant issue for medical professionals, impacting well-being and patient care.
Existing explanations for fatigue, like stress and lifestyle, are insufficient.
The oral microbiome's role in fatigue requires further investigation.

Purpose of the Study:

To explore the longitudinal relationship between oral microbiome diversity and fatigue in first-year medical students.
To assess how lifestyle, stress, and sleep correlate with fatigue and oral microbial changes.
To identify potential microbial markers or modulators of fatigue in this population.

Main Methods:

Longitudinal study design with four timepoints over one academic year.
Collection of buccal swabs for 16S rRNA sequencing and microbiome analysis (QIIME2).
Administration of standardized questionnaires for stress (PSS), sleep quality (PSQI), and fatigue (FAS).

Main Results:

Significant increases in self-reported fatigue were observed throughout the year.
Oral microbiome alpha diversity showed fluctuations, peaking mid-year and then declining.
Associations were noted between fatigue levels and microbiome richness, suggesting a link between physiological fatigue and microbial variability.

Conclusions:

Oral microbiome diversity fluctuates in first-year medical students, potentially adapting to environmental and physiological stressors.
Fatigue and microbial variability appear interconnected, warranting further research into causal relationships.
Modulating the oral microbiome could be a novel therapeutic strategy for alleviating fatigue in medical trainees.