Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

21.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
21.6K
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

1.1K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
1.1K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.3K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.3K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

502
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
502
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

702
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
702
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

700
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
700

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial Activity and Mode of Action of N-Heterocyclic Carbene Silver(I) Complexes.

Molecules (Basel, Switzerland)·2025
Same author

A CD Study of a Structure-Based Selection of <i>N</i>-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence.

Molecules (Basel, Switzerland)·2024
Same author

Mechanistic Evaluations of the Effects of Auranofin Triethylphosphine Replacement with a Trimethylphosphite Moiety.

Inorganic chemistry·2023
Same author

Structure-Activity Relationships in NHC-Silver Complexes as Antimicrobial Agents.

Molecules (Basel, Switzerland)·2023
Same author

New Insights into the Behavior of NHC-Gold Complexes in Cancer Cells.

Pharmaceutics·2023
Same author

Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides.

Molecules (Basel, Switzerland)·2021

Related Experiment Video

Updated: Sep 26, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.3K

Metal Complexes in Diagnosis and Therapy.

Diego Tesauro1

  • 1Interuniversity Research Centre on Bioactive Peptides (CIRPeB), Department of Pharmacy, University of Naples "Federico II", via Montesano, 49, 80131 Naples, Italy.

International Journal of Molecular Sciences
|April 23, 2022
PubMed
Summary

Metal complexes have been utilized for health and healing for thousands of years. This research explores their historical and potential therapeutic applications in modern medicine.

Area of Science:

  • Metallodrugs and inorganic medicinal chemistry.
  • Historical applications of metal-based therapies.
  • Biomedical applications of metal complexes.

Background:

  • The therapeutic use of metals dates back millennia.
  • Ancient civilizations employed metal compounds for medicinal purposes.
  • Evidence suggests early understanding of metal-based healing properties.

Discussion:

  • Review of historical metal-based treatments.
  • Analysis of efficacy and toxicity of ancient remedies.
  • Bridging historical knowledge with modern scientific understanding.

Key Insights:

  • Metal complexes possess long-standing therapeutic potential.
  • Historical practices offer insights into metallodrug development.

More Related Videos

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

58.0K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.1K

Related Experiment Videos

Last Updated: Sep 26, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.3K
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

58.0K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.1K
  • Understanding past applications informs future research.

    • Outlook:

    • Exploring novel metal complexes for contemporary diseases.
    • Investigating mechanisms of action for historical metallodrugs.
    • Developing safer and more effective metal-based therapeutics.