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Published on: November 11, 2020
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Predictive value of collagen in cancer
Peggi M Angel1, Stephen C Zambrzycki1
1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.
Advances in Cancer Research
|April 23, 2022
Summary
Collagen in the tumor microenvironment impacts cancer progression and metastasis. Assays measuring collagen show high predictive value for monitoring cancer and patient outcomes.
Area of Science:
- Oncology
- Biochemistry
- Extracellular Matrix Biology
Background:
- Cancer is a leading cause of global mortality.
- Collagen, a key component of the tumor microenvironment (TME), significantly influences cancer development, progression, and metastasis across various cancer types.
- Understanding collagen's role in the TME is crucial for advancing cancer diagnostics and therapeutics.
Purpose of the Study:
- To review the regulation of collagen within the tumor microenvironment.
- To discuss the pathological involvement of collagen in cancer.
- To evaluate the predictive value of collagen and related extracellular matrix (ECM) components in major cancer types.
Main Methods:
- Literature review focusing on collagen regulation and function in the TME.
- Analysis of existing studies on collagen's pathological roles in cancer.
- Survey of predictive tests and collagen assays utilizing clinical data.
Main Results:
- Collagen dynamics within the TME are integral to cancer emergence, progression, and metastasis.
- Collagen and associated ECM components demonstrate significant predictive capabilities for cancer monitoring.
- Clinical cohort studies highlight the utility of collagen assays in stratifying patient outcomes.
Conclusions:
- Collagen exhibits high predictive value for monitoring cancer progression and stratifying patients based on outcomes.
- Further research into the molecular aspects of collagen in cancer is warranted.
- Novel approaches are needed to fully elucidate collagen's multifaceted role in oncology.
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