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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

846
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
846

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Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
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Plumbing our organs: Lessons from vascular development to instruct lab generated tissues.

Anne R Ryan1, Ondine Cleaver1

  • 1Department of Molecular Biology, Center for Regenerative Science and Medicine (CRSM), University of Texas Southwestern Medical Center, Dallas, TX, United States.

Current Topics in Developmental Biology
|April 24, 2022
PubMed
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Understanding embryonic blood vessel development is key to vascularizing lab-grown organs. This knowledge helps improve organoid technologies and advance regenerative medicine for better organ function.

Keywords:
Blood vesselEndothelial cell heterogeneityEndotheliumKidneyOrganogenesisOrganoidsRenal

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Area of Science:

  • Developmental biology
  • Regenerative medicine
  • Vascular biology

Background:

  • Organ development relies on coordinated growth with intricate vasculature.
  • Endothelial cells (ECs) are crucial gatekeepers for circulation-organ communication.
  • Understanding ECs' embryonic assembly and vascular tree expansion is vital.

Purpose of the Study:

  • Review knowledge of embryonic blood vessel formation.
  • Assess current approaches to vascularizing laboratory-generated tissues (organoids).
  • Discuss challenges in achieving patterned vascular networks in organoids.

Main Methods:

  • Review of existing literature on embryonic vascular development.
  • Analysis of recent studies on kidney vasculature and organoid vascularization.
  • Assessment of challenges and limitations in organoid technology.

Main Results:

  • Embryonic vascular development provides insights for organoid vascularization.
  • Kidney organoid vascularization faces challenges in network patterning.
  • Recent studies offer potential approaches to improve organoid vascularization.

Conclusions:

  • Knowledge of organ-specific vasculogenesis aids regenerative therapies.
  • Improved vascularization is essential for functional organoids.
  • Further research into vascular development will drive therapeutic advancements.