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Updated: Sep 26, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Yue Zhang1, Xinyi Zhang1, Yumeng Xu1

  • 1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.

Frontiers in Oncology
|April 25, 2022
PubMed

Insights

Circular RNAs (circRNAs) are stable molecules involved in biological events, including cancer. This review details circRNA functions and their potential as cancer biomarkers for diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with high abundance, specificity, and stability.
  • They are primarily formed through the reverse splicing of precursor mRNAs.
  • circRNAs play crucial roles in various biological processes, notably in cancer development.

Purpose of the Study:

  • To review the classification, characterization, biogenesis, and functions of circRNAs.
  • To highlight the latest advancements in circRNA research concerning cancer.
  • To explore the potential of circRNAs as biomarkers for cancer diagnosis and therapy.

Main Methods:

  • Literature review of existing studies on circRNAs and cancer.
  • Analysis of circRNA classification, biogenesis pathways, and functional mechanisms.
  • Synthesis of current findings on circRNAs in cancer research and biomarker development.

Main Results:

  • circRNAs exhibit diverse functions and mechanisms relevant to biological events, including cancer.
  • Significant progress has been made in understanding circRNA roles in cancer occurrence and progression.
  • circRNAs show promise as novel biomarkers for cancer detection and treatment strategies.

Conclusions:

  • circRNAs are critical regulators in biological systems and disease.
  • Further research into circRNAs offers new avenues for cancer diagnostics and therapeutics.
  • The stability and specificity of circRNAs make them valuable targets for future studies.
Keywords:
biogenesisbiomarkerscancercircRNAsmechanisms

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