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MRKNs: Gene, Functions, and Role in Disease and Infection

Tongtong Wang1, Wenqiang Liu1, Changfa Wang1

  • 1College of Agronomy, Liaocheng University, Liaocheng, China.

Frontiers in Oncology
|April 25, 2022
PubMed

Insights

Makorin RING finger proteins (MKRNs) function as E3 ligases, regulating cellular components via the ubiquitin-proteasome system. This review details MKRNs

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The makorin RING finger protein (MKRN) gene family encodes proteins with conserved RING finger domains.
  • These proteins function as RING finger E3 ligases, crucial for the ubiquitin-proteasome system (UPS).
  • MKRNs regulate diverse cellular components, including p53, p21, and PTEN.

Purpose of the Study:

  • To systematically review advances in MKRN gene expression and function.
  • To elucidate the role of MKRN orthologs in various diseases and pathogen infections.
  • To explore the potential of MKRNs as therapeutic targets.

Main Methods:

  • Systematic literature review of gene expression and function studies.
  • Analysis of MKRN roles in disease pathogenesis.
  • Investigation of MKRN involvement in host-pathogen interactions.

Main Results:

  • MKRNs are involved in diverse cellular processes and disease states, including cancer, metabolic disorders, and neurodevelopment.
  • Specific MKRNs (MKRN1-4) have distinct roles, such as MKRN3 in central precocious puberty and MKRN4 in systemic lupus erythematosus.
  • MKRNs play a role in regulating responses to viral and bacterial infections.

Conclusions:

  • MKRNs are versatile E3 ligases with significant roles in cellular regulation and disease.
  • Understanding MKRN function provides insights into disease mechanisms and potential therapeutic strategies.
  • MKRNs represent promising targets for host innate antiviral defenses and disease treatment.
Keywords:
diseaseinfectionmakorin RING finger protein (MKRN)regulationrole

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