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Related Experiment Videos

Localized cutaneous cryptococcosis successfully treated with ketoconazole.

F Granier, J Kanitakis, C Hermier

    Journal of the American Academy of Dermatology
    |January 1, 1987
    PubMed
    Summary

    Cutaneous cryptococcosis, a fungal skin infection, can occur in renal transplant patients. Early diagnosis and treatment with ketoconazole led to successful healing without systemic spread.

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    Area of Science:

    • Medical Mycology
    • Transplant Immunology
    • Dermatology

    Background:

    • Renal allograft recipients on immunosuppressants (steroids, azathioprine) are susceptible to opportunistic infections.
    • Cutaneous manifestations can be the initial sign of fungal infections in immunocompromised individuals.

    Observation:

    • A 27-year-old female renal transplant recipient presented with progressive ulcerative, nodular, and abscessed skin lesions.
    • Histopathology and tissue cultures confirmed cutaneous cryptococcosis.
    • Light and electron microscopy detailed the fungal morphology within the skin.

    Findings:

    • Systemic involvement was ruled out through comprehensive visceral investigation.
    • Treatment with oral ketoconazole (400 mg daily) for 6 months resulted in gradual lesion healing.

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  • Fungal cultures became negative three months into treatment, indicating therapeutic success.

    • Implications:

    • This case highlights the importance of recognizing cutaneous fungal infections in transplant patients.
    • Prompt diagnosis and appropriate antifungal therapy (ketoconazole) can effectively manage localized cryptococcosis.
    • Successful treatment prevents dissemination, improving patient outcomes and graft survival.