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The Roles of Noncoding RNAs in Systemic Sclerosis
Yongmei Liu1,2, Linlin Cheng1,2, Haoting Zhan1,2
1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Frontiers in Immunology
|April 25, 2022
Summary
Noncoding RNAs (ncRNAs) are functional molecules involved in critical cellular processes. This review explores their role in systemic sclerosis (SSc), highlighting potential diagnostic and therapeutic applications.
Area of Science:
- Molecular Biology
- Genomics
- Immunology
Background:
- Noncoding RNAs (ncRNAs) comprise over 90% of human genomic RNA.
- Initially considered "junk" DNA, ncRNAs are now recognized as key regulators of cellular functions.
- Aberrant ncRNA expression is implicated in diseases, including autoimmune conditions like systemic sclerosis (SSc).
Purpose of the Study:
- To review current knowledge on ncRNA biogenesis and function.
- To explore the role of ncRNAs, including microRNAs and long noncoding RNAs, in systemic sclerosis (SSc).
- To discuss emerging ncRNA-based diagnostic and therapeutic strategies for SSc.
Main Methods:
- Literature review of studies on ncRNAs and systemic sclerosis.
- Analysis of ncRNA functions in cellular processes and disease mechanisms.
- Synthesis of current findings on ncRNA biomarkers and therapeutics for SSc.
Main Results:
- ncRNAs regulate crucial biological processes such as gene expression and signaling pathways.
- Evidence suggests specific ncRNAs are dysregulated in SSc, indicating their involvement in pathogenesis.
- ncRNAs show promise as potential biomarkers for SSc diagnosis and as targets for novel therapies.
Conclusions:
- ncRNAs are critical regulators with significant roles in systemic sclerosis.
- Further research into ncRNA mechanisms in SSc is needed to fully understand their potential.
- ncRNA-based diagnostics and therapeutics represent a promising frontier for SSc management.
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