Related Experiment Video
Updated: Sep 25, 2025
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Psoriasis and Myasthenia Gravis: A Common Th-17 Pathway
Fouad El Sayed1, Mariam Kabbani1
1Dermatology, Lebanese University Faculty of Medicine, Beirut, LBN.
Cureus
|April 25, 2022
Summary
A patient with severe psoriasis and myasthenia gravis experienced skin lesion clearance and symptom remission with ixekizumab. This interleukin-17 (IL-17) inhibitor allowed for corticosteroid tapering, suggesting IL-17
Area of Science:
- Immunodermatology
- Neuromuscular Diseases
Background:
- Psoriasis management is complicated by comorbidities.
- Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions.
Observation:
- A 55-year-old female with severe chronic plaque psoriasis and steroid-dependent myasthenia gravis (MG) was treated with ixekizumab.
- Previous treatments including topical corticosteroids and phototherapy were ineffective for her psoriasis.
Findings:
- Ixekizumab, an anti-interleukin-17 (IL-17) antibody, achieved complete clearance of psoriatic lesions.
- The patient experienced significant remission of myasthenic symptoms, enabling a reduction in oral corticosteroid dosage.
Implications:
- This case suggests a potential role for IL-17 cytokines in the pathogenesis of myasthenia gravis.
- Ixekizumab may represent a novel therapeutic option for patients with coexisting psoriasis and steroid-dependent myasthenia gravis.
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