Related Experiment Video
Updated: Sep 25, 2025
10:22
High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
Published on: September 2, 2009
13.9K
Recent advances in remotely controlled pulsatile drug delivery systems
Al Zahraa Khalifa1, Houralaeen Zyad1, Hoor Mohammed1
1Department of Pharmaceutics, Dubai Pharmacy College, Dubai, UAE.
Journal of Advanced Pharmaceutical Technology & Research
|April 25, 2022
Summary
Externally regulated pulsatile drug delivery systems offer precise, on-demand therapeutic control. Recent advances in responsive technologies enhance drug delivery timing, duration, and location for improved patient compliance and customizable therapy.
Area of Science:
- Pharmaceutical Technology
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Conventional dosage forms lack precise control over drug release kinetics.
- Pulsatile delivery systems enhance therapeutic efficacy and patient compliance.
- Advancements are needed for on-demand and site-specific drug administration.
Purpose of the Study:
- To review recent advances in externally regulated pulsatile drug delivery systems.
- To highlight remotely controlled pulsatile release technologies.
- To discuss the current status and future applications of these systems.
Main Methods:
- Review of recent literature on advanced pulsatile drug delivery systems.
- Focus on electro-responsive, light-responsive, ultrasound-responsive, and magnetically-induced systems.
- Inclusion of wirelessly controlled implantable systems.
Main Results:
- Externally regulated systems offer precise control over drug release timing, duration, and location.
- Responsive technologies enable on-demand and customizable drug delivery.
- Significant progress has been made in remotely controlled pulsatile systems.
Conclusions:
- Externally regulated pulsatile systems represent a significant advancement in pharmaceutical technology.
- These systems hold great promise for improved therapeutic outcomes and patient care.
- Further research and development are expected to expand their clinical applications.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
494
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
494
01:16Drug Delivery: Overview
443
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
443
01:29Drug Delivery: Parenteral Route
932
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
932
01:25Routes of Drug Administration: Parenteral
2.2K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.2K
01:18Additional Routes of Drug Administration
3.2K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
3.2K
01:15Non-Oral Extravascular Drug Absorption Routes
314
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
314