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Metastatic neuroblastoma presenting without a primary tumor: A case report
Ahmed Hafez Mousa1, Abdullah Baothman2, Abdelrahman Waleed Alsayed1
1Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia.
Radiology Case Reports
|April 25, 2022
Summary
This case highlights metastatic neuroblastoma presenting solely as cervical lymphadenopathy in a child. It emphasizes recognizing this rare presentation without an obvious primary tumor.
Area of Science:
- Pediatric Oncology
- Oncology
- Immunophenotyping
Background:
- Neuroblastoma is a common childhood extracranial tumor, typically originating in the adrenal glands.
- Classical presentation involves an abdominal mass, often painless, with or without associated pain.
Observation:
- A 4-year-old female presented with recurrent fever, joint pain, and subtle cervical lymph node enlargement.
- Initial investigations showed anemia and elevated inflammatory markers, suggesting an inflammatory or infectious process.
Findings:
- Immunohistochemistry and immunophenotyping confirmed metastatic neuroblastoma in cervical lymph nodes and bone marrow.
- The diagnosis was established in the absence of a detectable primary tumor, a unique clinical presentation.
Implications:
- This case underscores the importance of considering metastatic neuroblastoma in pediatric patients with unexplained lymphadenopathy, even without a clear primary tumor.
- Early recognition of atypical presentations is crucial for timely diagnosis and treatment of pediatric neuroblastoma.
