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Rezūm therapy for ≥80-mL benign prostatic enlargement: a large, multicentre cohort study
Dean Elterman1, Naeem Bhojani2, Christopher Vannabouathong1
1Division of Urology, University Health Network, University of Toronto, Toronto, ON, Canada.
BJU International
|April 25, 2022
Summary
Rezūm therapy effectively treats benign prostatic hyperplasia (BPH) in large prostates (≥80 mL), significantly improving symptoms and urinary flow. Erectile and ejaculatory functions were preserved, demonstrating a safe and effective treatment option.
Area of Science:
- Urology
- Minimally Invasive Therapies
- Prostate Health
Background:
- Benign prostatic hyperplasia (BPH) is a common condition affecting aging men.
- Large prostate volumes (≥80 mL) present treatment challenges.
- Current BPH treatments may have limitations in efficacy or side effects.
Purpose of the Study:
- To evaluate the safety and efficacy of Rezūm therapy for BPH in patients with large prostates (≥80 mL).
- To assess the impact of Rezūm therapy on lower urinary tract symptoms and quality of life.
- To determine the effect on objective urinary flow measures and sexual function.
Main Methods:
- Prospective registry study conducted at two Canadian centers.
- Included 83 patients with prostate volume ≥80 mL.
- Collected baseline data and followed patients for 12 months, recording uroflowmetry and validated questionnaires (IPSS, QoL, BPH Impact Index, IIEF-15, MHS-ED).
Main Results:
- Significant improvements observed in International Prostate Symptom Scores (IPSS) by 59% and Quality of Life (QoL) scores by 70% at 12 months (P < 0.001).
- Maximum urinary flow rate improved by 59% at 12 months (P = 0.002), and post-void residual urine volume decreased by 58% at 3 months (P = 0.006).
- Erectile function showed a 15% improvement, and ejaculatory dysfunction was reported by only 3.6% of patients, with no severe adverse events (Clavien-Dindo grade III or higher).
Conclusions:
- Rezūm therapy is a safe and effective treatment option for BPH in patients with large prostate glands (>80 mL).
- The therapy leads to substantial and sustained improvements in symptom scores and urinary flow.
- Preservation of erectile and ejaculatory function supports Rezūm therapy as a favorable treatment choice.
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