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Updated: Sep 25, 2025

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Glass-Based Devices to Generate Drops and Emulsions
Published on: April 5, 2022
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Glass-Based Devices to Generate Drops and Emulsions
Josefa Guerrero1, Javier Rojo2, Alexis de la Cotte2
1Department of Chemistry and Physics, Augusta University; jguerreromillan@augusta.edu.
Journal of Visualized Experiments : Jove
|April 25, 2022
Summary
This study presents three microfluidic methods for creating uniform emulsion drops. Electrified drops, generated using an electric field, allow for smaller sizes and diverse particle/fiber production.
Area of Science:
- Materials Science
- Chemical Engineering
- Fluid Dynamics
Background:
- Microfluidic devices offer precise control over fluid interfaces.
- Generating highly monodisperse emulsion drops is crucial for various applications.
- Existing methods may have limitations in drop size control and versatility.
Purpose of the Study:
- To describe three distinct protocols for generating highly monodisperse emulsion drops using glass-based microfluidics.
- To explore the impact of gravity, coflowing streams, and electric fields on drop formation.
- To demonstrate the generation of electrified drops and their subsequent discharge.
Main Methods:
- Development of three glass-based microfluidic devices.
- Protocol 1: Gravity-driven simple drop generation.
- Protocol 2: Coflowing stream-based emulsion drop generation.
- Protocol 3: Electrified drop generation using a dielectric mediating liquid and applied voltage.
Main Results:
- Successful generation of highly monodisperse emulsion drops across all three protocols.
- Demonstration of smaller drop sizes achievable with the electrified drop generation method compared to simple coflow.
- Capability to produce particles and fibers with a wide range of sizes by manipulating electric fields and hydrodynamic stresses.
Conclusions:
- The presented microfluidic protocols provide versatile and controllable methods for emulsion drop generation.
- The integration of electric fields offers enhanced control over drop size and morphology.
- These techniques are valuable for producing tailored microparticles and nanofibers for diverse applications.

