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Piperine: An Anticancer and Senostatic Drug

Jae Sung Lim1,2, Da Young Lee1, Ju Hyeon Lim3

  • 1Department of Biochemistry, Chonnam National University Medical School, 58128 Jeonnam-do, Republic of Korea.

Frontiers in Bioscience (Landmark Edition)
|April 25, 2022
PubMed
Abstract

Insights

Piperine effectively targets cancer cells and senescent cells, offering a dual approach to cancer treatment by inducing senostatic effects and eliminating cancer cells. This study positions piperine as a primary cancer therapeutic, not an adjunct therapy.

Area of Science:

  • Oncology
  • Gerontology
  • Cell Biology

Background:

  • Cancer is linked to aging and senescent cells, which impede cancer treatments via SASP secretion.
  • Targeting both cancer and senescent cells is crucial for effective cancer therapy.
  • Piperine is investigated for its potential as a senostatic and anticancer agent.

Purpose of the Study:

  • To investigate the selective effects of piperine on cancer and senescent cells.
  • To evaluate piperine's potential as a senostatic agent and anticancer drug.

Main Methods:

  • Cytotoxicity and proliferation assays (LDH, WST).
  • Western blot analysis for p16INK4a, p21, MAPKs, and mTOR.
  • Assessment of senescence markers (SA-β-Gal, MMP, ROS) and SASP secretion.

Main Results:

  • Piperine exhibited high cytotoxicity in cancer cell lines.
  • Piperine promoted proliferation in senescent cells, similar to nicotinamide.
  • Piperine modulated intracellular pathways, reversed senescence phenotypes, and altered SASP in senescent cells.

Conclusions:

  • Piperine demonstrates selective effects on cancer and senescent cells.
  • Piperine acts as a senostatic agent and anticancer drug.
  • Piperine is proposed as a standalone cancer treatment for simultaneous senostasis and cancer cell removal.
Keywords:
anticancerhuman diploid fibroblastspiperinesenescencesenescence-associated secretory phenotypesenostatic

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