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Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Related Experiment Video

Updated: Sep 25, 2025

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

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Published on: June 15, 2020

Publisher Correction: SLEAP: A deep learning system for multi-animal pose tracking

Talmo D Pereira^1,2, Nathaniel Tabris¹, Arie Matsliah¹

¹Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.

|April 26, 2022

Summary

No abstract available in PubMed .

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