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Changes in Cough Reflex Sensitivity in Children After Removal of Hypertrophied Adenoid Tissue

Jan Sojak1, Peter Durdik2, Eva Omar Mohamedova3

  • 1Clinic of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Slovak Medical University in Bratislava, Central Military Hospital in Ruzomberok, Ruzomberok, Slovak Republic.

Journal of Asthma and Allergy
|April 26, 2022
PubMed

Insights

Adenoidectomy significantly improves cough reflex sensitivity in children with chronic cough. This surgical intervention reduces the concentration of capsaicin needed to trigger a cough, indicating enhanced sensitivity post-procedure.

Area of Science:

  • Pediatric Pulmonology
  • Otolaryngology
  • Respiratory Medicine

Background:

  • Chronic cough and adenoid hypertrophy are frequently observed together in pediatric patients.
  • Understanding the impact of adenoid tissue on cough reflex sensitivity is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine the effect of adenoid tissue removal on cough reflex sensitivity in children.
  • To quantify changes in the threshold for cough provocation following adenoidectomy.

Main Methods:

  • A cohort of 17 children (aged 4-12) with chronic cough and adenoids underwent cough reflex sensitivity testing before and after endoscopic adenoidectomy.
  • Cough reflex sensitivity was assessed using capsaicin aerosol in ascending concentrations, measuring the lowest concentration to elicit two (C2) or five (C5) coughs.

Main Results:

  • Post-adenoidectomy, cough sensitivity showed a trend towards improvement for C2 (31.86 to 11.97 µmol/L, P=0.064) and a significant improvement for C5 (234.91 to 69.13 µmol/L, P=0.022).
  • Pulmonary function tests remained within normal limits for all participants throughout the study.

Conclusions:

  • Adenoidectomy leads to a significant increase in cough reflex sensitivity in non-atopic children experiencing chronic cough.
  • Surgical removal of adenoid tissue may be an effective intervention for managing chronic cough in this pediatric population.
Abstract

Keywords:
adenoidectomyadenoidschildrenchronic coughcoughcough reflex sensitivity

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