Related Experiment Video
Updated: Sep 25, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Pharmacogenomics of Drug Hypersensitivity: Technology and Translation
Rebecca Kuruvilla1, Kathryn Scott1, Sir Munir Pirmohamed1
1Department of Pharmacology and Therapeutics, Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, L69 3GL, UK.
Abstract:
Hypersensitivity reactions are caused by many structurally unrelated drugs used for many different diseases. These reactions vary in severity and can be fatal. Only a minority of patients are affected by drug hypersensitivity reactions. Predisposition seems to be mediated by genetic factors, particularly within the HLA system. Apart from HLA-B∗57:01 testing, which is routine to prevent abacavir hypersensitivity, uptake of HLA testing into clinical practice has been slow and challenging. As genomic medicine becomes mainstream, it will be important for genetic testing in this area to move from the current reactive strategy to a more pre-emptive approach.
Related Concept Videos
Desensitization and Tachyphylaxis
Factors Affecting Drug Response: Overview
Drug Discovery: Overview
Nonlinear Pharmacokinetics: Role of Transporters
Polymorphisms occurring in drug transporters can alter...
Analysis of Population Pharmacokinetic Data
Allergic Drug Reactions

