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Layered supramolecular hydrogels from thioglycosides.

Yu-Cheng Wang1, Laurel L Kegel1, David S Knoff2

  • 1Department of Chemistry and Biochemistry, University of Arizona, 1306 E University Boulevard, Tucson, Arizona 85721, USA. pembertn@email.arizona.edu.

Journal of Materials Chemistry. B
|April 26, 2022
PubMed
Summary

This study characterizes novel low molecular weight hydrogels from lactose and cellobiose. Thiolactoside hydrogels are robust and thixotropic, while thiocellobioside gels form metastable fibrous crystals.

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry

Background:

  • Low molecular weight hydrogels self-assemble via noncovalent interactions.
  • Characterizing their physical and chemical properties is crucial for applications.

Purpose of the Study:

  • To comprehensively characterize hydrogels derived from thioglycolipids of lactose and cellobiose.
  • To explore their structural, thermal, and mechanical properties.

Main Methods:

  • Rheology to determine viscoelastic properties.
  • Freeze-fracture electron microscopy for structural analysis.
  • Differential scanning calorimetry and fluorescence spectroscopy for phase transitions.

Main Results:

  • Thiolactoside hydrogels are robust and thixotropic; thiocellobioside gels are metastable, forming fibrous crystals.
  • Rheology shows viscoelastic solid behavior (10-600 kPa storage moduli).
  • Unique stacked sheet structures observed in xerogels; phase transitions range from 30-80 °C.

Conclusions:

  • These hydrogels exhibit unique properties, including tunable phase transitions and distinct microstructures.
  • Thiolactoside hydrogels possess desirable thixotropic properties for potential applications.
  • The study provides insights into structure-property relationships for self-assembled carbohydrate-based materials.