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Updated: Sep 25, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

[Biomanufacturing driven by engineered microbes].

¹CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology

|April 26, 2022

Summary

This summary is machine-generated.

This review highlights 2021 biomanufacturing advances using engineered microbes like Escherichia coli and yeast. It covers key products and technologies, offering insights into microbial engineering research trends.

Keywords:

biomanufacturing cell factories engineered microbes primary metabolites secondary metabolites synthetic biology

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Last Updated: Sep 25, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

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Published on: December 15, 2017

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Published on: November 16, 2012

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

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Published on: March 9, 2017

Area of Science:

Biotechnology
Synthetic Biology
Metabolic Engineering

Background:

Biomanufacturing is crucial for sustainable production of chemicals and materials.
Engineered microbes serve as key platforms for biomanufacturing processes.

Purpose of the Study:

To summarize the state-of-the-art in biomanufacturing research published in the Chinese Journal of Biotechnology in 2021.
To provide an overview of microbial chassis, target products, and enabling technologies in the field.

Main Methods:

Comprehensive review of peer-reviewed articles and research papers from 2021.
Categorization of studies based on microbial chassis, product types, and technological approaches.

Main Results:

Significant progress was reported across diverse microbial chassis, including Escherichia coli, Bacillus subtilis, Corynebacterium glutamicum, Saccharomyces cerevisiae, and others.
Advances were detailed in the production of amino acids, organic acids, vitamins, natural compounds, biopolymers, and the utilization of biomass and C1 compounds.
Key technologies such as metabolic regulation, directed evolution, and high-throughput screening were highlighted as crucial for constructing efficient cell factories.

Conclusions:

The field of biomanufacturing driven by engineered microbes is rapidly advancing.
Continued innovation in microbial engineering and synthetic biology will further expand the scope and efficiency of biomanufacturing.