Related Experiment Video
Updated: Sep 25, 2025

Light-Controlled Fermentations for Microbial Chemical and Protein Production
Published on: March 22, 2022
[Tolerance engineering regulates stress resistance of microbial cell factory]
Li Zhang1, Jian Gao1, Changqing Liu1
1College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 224051, Jiangsu, China.
Abstract:
The production efficiency of microbial cell factory is determined by the growth performance, product synthetic capacity, and stress resistance of the strain. Strengthening the stress resistance is the key point to improve the production efficiency of microbial cell factory. Tolerance engineering is based on the response mechanism of microbial cell factory to resist stress. Specifically, it consolidates the cell wall-cell membrane barrier to enhance the defense against stress, accelerates the stress response to improve the damage repair, and creates tolerance evolutionary tools to screen industrial microorganisms with enhanced robustness. We summarize the regulation strategies and forecast the prospects of tolerance engineering, which plays an important role in the microbial cell factories for sustainable production of natural products and bulk chemicals.
Related Concept Videos
Other Stress Responses in Bacteria
Stringent Response in E. coli
Global Regulatory Systems
Methods for Controlling Microbial Growth
Constitutive and Regulated Gene Expression
Gene Regulation During Sporulation

