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Updated: Sep 25, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
Commentary on achievement of first life-saving xenoheart transplant
1United Therapeutics Corporation, Public Benefit Company, 1000 Spring Street, Silver Spring, Maryland, 20910, USA.
Abstract:
Two months of post-transplant survival were achieved in an end-stage heart disease patient with a porcine heart from a pig whose genome had been modified in 10 of its genes. This first-ever life-saving cardiac xenotransplantation was the result of decades of work and close coordination by researchers in genetic engineering, animal cloning, immunology, ex vivo organ perfusion, and thoracic surgery.
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