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Updated: Sep 25, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Everyday function profiles in prodromal stages of MCI: Prospective cohort study
Joe Verghese1,2, Pierfilippo De Sanctis1,3, Emmeline Ayers1
1Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Introduction:
The nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known.
Methods:
We compared complex everyday functional profiles at baseline in 59 community-dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) ("pre-MCI") with 284 older individuals who remained cognitively normal over follow-up.
Results:
The mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre-MCI cases and 2.0 ± 2.4 in the 284 normal controls (P = .003). Pre-MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre-MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P < .001).
Discussion:
Prodromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.
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