Management of Tricky Lymphoma Cases

Area of Science:

• Ophthalmology
• Oncology
• Pathology

Background:

• Lymphoma lesions in the eye are common but exhibit diverse clinical presentations.
• Variability in patient history, clinical signs, and management approaches complicates diagnosis.
• Lymphoma can present insidiously, resembling benign conditions like dermatochalasis, or acutely, mimicking an abscess.

Purpose of the Study:

• To highlight the varied presentations of ocular lymphoma.
• To emphasize critical diagnostic considerations for unexpected lymphoma findings.
• To underscore the importance of timely and strategically located biopsies.

Main Methods:

• Retrospective analysis of seven cases (ages 40-93) with unexpected ocular lymphoma.
• Review of clinical history, imaging, intraoperative findings, and biopsy results.
• Correlation of clinical, imaging, and pathological data.

Main Results:

• Demonstrated significant variability in patient history, clinical presentation, and management.
• Observed lymphoma progression mimicking conditions from dermatochalasis to abscess.
• Confirmed the utility of simple subconjunctival biopsy for retrobulbar lesions.

Conclusions:

• Accurate diagnosis of ocular lymphoma requires correlating clinical, imaging, and intraoperative findings.
• Early and carefully selected biopsy site is essential for definitive diagnosis.
• Individualized management strategies should integrate patient history and systemic findings.