Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chirality02:25

Chirality

25.9K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
25.9K
Chirality in Nature02:30

Chirality in Nature

14.0K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
14.0K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

2.0K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
2.0K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

12.8K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
12.8K
Prochirality02:05

Prochirality

4.0K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.0K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

6.0K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling ferroptosis in postmortem pork: Mechanistic insights and implications for lipid oxidation induced meat quality development.

Food chemistry·2025
Same author

Spatial Blind Source Estimation of Respiratory Rate and Heart Rate Detection Based on Frequency-Modulated Continuous Wave Radar.

Sensors (Basel, Switzerland)·2025
Same author

Silicon bowtie structure based adjustable nonrigid all-nonmetal metamaterial terahertz filter.

Optics letters·2023
Same author

Topography Mapping with Scanning Electrochemical Cell Microscopy.

Analytical chemistry·2022
Same author

Diminished 25-OH vitamin D<sub>3</sub> levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases.

Journal of clinical laboratory analysis·2019
Same author

Isolation and characterization of <i>Bordetella pseudohinzii</i> in mice in China.

Animal models and experimental medicine·2019

Related Experiment Video

Updated: Sep 25, 2025

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
07:28

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor

Published on: August 30, 2012

10.9K

Chiral biosensing using terahertz twisted chiral metamaterial.

Min Zhang, Danni Hao, Shuai Wang

    Optics Express
    |April 27, 2022
    PubMed
    Summary

    Researchers developed a tunable chiral metamaterial for detecting biochemical samples. This novel structure enables label-free detection and enantio-discrimination of chiral molecules using terahertz waves.

    More Related Videos

    Simulation, Fabrication and Characterization of THz Metamaterial Absorbers
    13:44

    Simulation, Fabrication and Characterization of THz Metamaterial Absorbers

    Published on: December 27, 2012

    15.5K
    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
    09:28

    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

    Published on: January 10, 2017

    8.3K

    Related Experiment Videos

    Last Updated: Sep 25, 2025

    Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
    07:28

    Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor

    Published on: August 30, 2012

    10.9K
    Simulation, Fabrication and Characterization of THz Metamaterial Absorbers
    13:44

    Simulation, Fabrication and Characterization of THz Metamaterial Absorbers

    Published on: December 27, 2012

    15.5K
    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
    09:28

    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

    Published on: January 10, 2017

    8.3K

    Area of Science:

    • Metamaterials Science
    • Chirality Studies
    • Terahertz Spectroscopy

    Background:

    • Subwavelength chiral metamaterials are crucial for detecting chiral biochemical samples.
    • Tunable geometries and compositions are needed for advanced detection capabilities.

    Purpose of the Study:

    • To design and investigate a novel spatial symmetry breaking chiral terahertz metamaterial.
    • To explore the tunability of chiroptical response by structural modifications.
    • To demonstrate the application of the metamaterial in label-free biosensing.

    Main Methods:

    • Fabrication of a chiral metamaterial using stacked layers of L-shape arranged gold disks.
    • Experimental and numerical simulation analysis of chiroptical response.
    • Investigation of label-free detection of proline and enantio-discrimination of chiral molecules.

    Main Results:

    • The chiroptical response is tunable by adjusting stacking layers and twist angles.
    • Optical resonances of gold disks and adjacent layers drive the chiroptical response.
    • Successful label-free detection of proline and enantio-discrimination of chiral molecules demonstrated.
    • Analyte concentration correlates with transmission circular dichroism (TCD) intensity.

    Conclusions:

    • The developed chiral metamaterial offers on-demand adjustable chiroptical properties.
    • This work provides new strategies for designing functional chiral metamaterials and chiroptical biosensing devices.