Related Experiment Video
Updated: Sep 25, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.4K
Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case-control study
Shanghao Chen1,2, Zezhong Wu1,2, Yan Yun3
1Department of Cardiovascular Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No.324 Jingwu Road, Jinan, 250021, Shandong, China.
BMC Cardiovascular Disorders
|April 27, 2022
Summary
The lymphocyte-to-monocyte ratio (LMR) is lower in patients with severe calcific aortic valve stenosis (CAVS)-related aortic dilation. This inflammatory biomarker is independently associated with this serious complication in CAVS patients.
Area of Science:
- Cardiovascular Medicine
- Inflammation Research
- Biomarker Discovery
Background:
- Calcific aortic valve stenosis (CAVS) poses a significant health risk, particularly to the elderly.
- Post-stenotic aortic dilation is a common CAVS feature that can lead to severe complications like aneurysms and dissections, indicating a poor prognosis.
Purpose of the Study:
- To investigate the association between the lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, and severe post-stenotic aortic dilation in Chinese patients with CAVS.
- To evaluate the prognostic value of LMR in predicting severe post-stenotic aortic dilation.
Main Methods:
- A retrospective case-control study involving 208 consecutive CAVS patients.
- Statistical analysis using ROC curves and binary logistic regression to assess LMR's prognostic value.
Main Results:
- LMR was significantly lower in patients with severe post-stenotic aortic dilation (2.72 vs. 3.53, p < 0.05).
- An inverse correlation was found between ascending aorta diameter and LMR (r = -0.217, p < 0.05).
- LMR was independently associated with severe post-stenotic aortic dilation (AUC 0.743, p = 0.025).
Conclusions:
- The study provides evidence of an inverse correlation between severe post-stenotic aortic dilation and LMR in CAVS patients.
- LMR is a potential independent predictor of severe post-stenotic aortic dilation.
