Related Experiment Video

Updated: Sep 25, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.7K

1,2,3-Triazole Derivatives with Anti-breast Cancer Potential

Xinyi Wu1, Jun Wang1, Shiqi Xia1

  • 1School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.

Current Topics in Medicinal Chemistry
|April 27, 2022
PubMed

Insights

Novel 1,2,3-triazole derivatives show significant potential as anti-breast cancer agents. This review highlights their mechanisms and structure-activity relationships, guiding the development of new therapies to combat drug resistance.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Breast cancer is a leading cause of mortality in women globally.
  • Chemotherapy resistance is a significant clinical challenge in breast cancer treatment.
  • There is a critical need for novel anti-breast cancer therapeutics.

Purpose of the Study:

  • To review the anti-breast cancer potential of 1,2,3-triazole derivatives.
  • To summarize recent advancements (2017-2021) in this field.
  • To discuss mechanisms of action and structure-activity relationships (SARs).

Main Methods:

  • Comprehensive literature search of scientific databases.
  • Analysis of studies on 1,2,3-triazole derivatives against breast cancer.
  • Synthesis of information on efficacy, mechanisms, and SARs.

Main Results:

  • 1,2,3-triazole derivatives demonstrate potent anti-proliferative, cell cycle arrest, and apoptotic effects against breast cancer cells.
  • Various derivatives exhibit significant efficacy, suggesting broad applicability.
  • SAR studies provide insights into optimizing molecular structures for enhanced activity.

Conclusions:

  • 1,2,3-triazole derivatives represent a promising class of compounds for breast cancer therapy.
  • Understanding their mechanisms and SARs is crucial for developing next-generation anti-cancer drugs.
  • Further research can accelerate the clinical translation of these agents.
Keywords:
123-TriazoleBreast cancerChemotherapyHeterogeneous diseaseMechanisms of actionStructure-activity relationship

More Related Videos

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs10:38

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

Published on: December 16, 2022

2.3K
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.4K

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
341
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.1K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
484
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K