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Mobile Subthreshold Exercise Program (MSTEP) for concussion: study protocol for a randomized controlled trial.

Sara P D Chrisman1,2, Beth J Bollinger3, Jason A Mendoza3,4,5

  • 1Center for Child Health, Behavior and Development, Seattle Children's Research Institute, PO Box 5371, CURE-03, Seattle, WA, 98145, USA. sara.chrisman@seattlechildrens.org.

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Summary
This summary is machine-generated.

This study tests a virtual subthreshold exercise program (MSTEP) for youth with persistent postconcussive symptoms (PPCS). The Mobile Subthreshold Exercise Program (MSTEP) aims to reduce symptoms and improve quality of life, offering a new treatment option.

Keywords:
Brain concussionChildClinical trialExercisePhysical activityRandomized controlled trial

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Area of Science:

  • Pediatric neurology
  • Sports medicine
  • Rehabilitation science

Background:

  • Persistent postconcussive symptoms (PPCS) in youth lack evidence-based treatment guidelines.
  • Previous exercise interventions for PPCS required multiple in-person visits, limiting accessibility.
  • A novel virtual approach, the Mobile Subthreshold Exercise Program (MSTEP), was developed for delivering subthreshold exercise.

Purpose of the Study:

  • To evaluate the efficacy of the Mobile Subthreshold Exercise Program (MSTEP) in reducing concussive symptoms in adolescents.
  • To assess the impact of MSTEP on health-related quality of life in youth with PPCS.
  • To investigate potential mediators of treatment effects, including physical activity and fear avoidance.

Main Methods:

  • A national randomized controlled trial (RCT) comparing MSTEP to an active control (stretching).
  • Recruitment of 200 adolescents aged 11-18 years with PPCS lasting 1 week to 1 year.
  • 6-week intervention with outcomes assessed over 6 months via surveys and objective measures.

Main Results:

  • Primary outcomes include the trajectory of concussive symptoms and health-related quality of life over 6 months.
  • Secondary outcomes encompass depression, anxiety, and sleep quality.
  • Assessment of mediators such as moderate-vigorous physical activity and fear avoidance.

Conclusions:

  • This multisite RCT will provide crucial data on the efficacy of virtually delivered subthreshold exercise for youth PPCS.
  • Findings will offer insights into mediators influencing treatment outcomes.
  • The study aims to establish MSTEP as a viable, accessible treatment for adolescent concussive symptoms.