Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prophylactic co-trimoxazole in biliary surgery.

C Morran, W McNaught, C S McArdle

    British Medical Journal
    |August 12, 1978
    PubMed
    Summary

    A single dose of co-trimoxazole significantly reduced septic complications, including wound sepsis and pulmonary issues, following elective cholecystectomy surgery. This prophylactic antibiotic treatment offers a promising strategy for improving patient outcomes in this surgical procedure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes B colorectal cancer.

    British journal of cancer·2010
    Same author

    The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up.

    British journal of cancer·2009
    Same author

    Colorectal liver metastases.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    Methods for relief of postoperative pain.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    The impact of old age on cancer-specific and non-cancer-related survival following elective potentially curative surgery for Dukes A/B colorectal cancer.

    British journal of cancer·2008
    Same author

    Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696).

    International journal of surgery (London, England)·2008

    Area of Science:

    • Surgical Infection Prevention
    • Clinical Pharmacology
    • Antimicrobial Therapy

    Background:

    • Septic complications pose a significant risk after elective cholecystectomy.
    • Infected bile is a common source of wound sepsis in these patients.
    • Effective prophylactic strategies are crucial for reducing surgical site infections.

    Purpose of the Study:

    • To evaluate the prophylactic efficacy of a single co-trimoxazole dose.
    • To assess the impact on septic complications after elective cholecystectomy.
    • To determine the effectiveness of co-trimoxazole in preventing post-operative infections.

    Main Methods:

    • A double-blind, placebo-controlled study design.
    • Inclusion of 95 patients undergoing elective cholecystectomy.
    • Administration of a single dose of co-trimoxazole versus placebo.

    Main Results:

    • Wound sepsis incidence decreased from 21% (controls) to 4% (co-trimoxazole group).
    • Pulmonary complication rates were significantly lower in the treated group (19% vs. 49%).
    • The observed differences in complication rates were statistically significant.

    Conclusions:

    • A single prophylactic dose of co-trimoxazole is effective in reducing septic complications post-cholecystectomy.
    • Co-trimoxazole achieves high plasma concentrations and is effective against common biliary pathogens.
    • This regimen represents a valuable approach to infection control in cholecystectomy patients.

    Related Experiment Videos