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Updated: Sep 25, 2025
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
TGF-β1 and CD68 immunoexpression in capsules formed by textured implants with and without mesh coverage: a study on
Ralf Berger1, Jurandir Marcondes Ribas Filho2, Marcelo Augusto de Souza3
1Fellow PhD degree. Postgraduate Program in Principles of Surgery - Faculdade Evangélica Mackenzie - Curitiba (PR), Brazil.
Purpose:
To evaluate fibrosis formation and number of macrophages in capsules formed around textured implants without and with mesh coverage.
Methods:
Fibrosis was analyzed through transforming growth factor-beta 1 (TGF-β1) immunomarker expression and the number of macrophages through CD68 percentage of cells in magnified field. Sixty female Wistar rats were distributed into two groups of 30 rats (unmeshed and meshed). Each group was then subdivided into two subgroups for postoperative evaluation after 30 and 90 days. The p value was adjusted by Bonferroni lower than 0.012.
Results:
No difference was observed in fibrosis between meshed and unmeshed groups (30 days p = 0.436; 90 days p = 0.079) and from 30 to 90 days in the unmeshed group (p = 0.426). The meshed group showed higher fibrosis on the 90th day (p = 0.001). The number of macrophages was similar between groups without and with mesh coverage (30 days p = 0.218; 90 days p = 0.044), and similar between subgroups 30 and 90 days (unmeshed p = 0.085; meshed p = 0.059).
Conclusions:
In the meshed group, fibrosis formation was higher at 90 days and the mesh-covered implants produced capsules similar to microtextured ones when analyzing macrophages. Due to these characteristics, mesh coating did not seem to significantly affect the local fibrosis formation.
