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Updated: Sep 25, 2025

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Pain levels during distraction osteogenesis with lengthening nails in 168 cases
Nikolaus Degen1,2, N de Almeida Lopes3,4, F Wolf3,4
1Workgroup 3D-Surgery, LMU Munich, Campus Innenstadt: Ziemssenstr. 1, 80336, Munich, Germany. ndegen@med.lmu.de.
Pain during lengthening nail (LN) distraction osteogenesis (DO) is low and decreases over time. Management primarily uses non-opioid pain relievers, indicating good tolerability in a large patient sample.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
Background:
- Distraction osteogenesis (DO) is a surgical technique used to lengthen bones.
- Lengthening nails (LN) are internal devices used to facilitate DO.
- Understanding pain levels during DO with LN is crucial for patient management.
Purpose of the Study:
- To assess pain levels experienced by patients undergoing distraction osteogenesis using lengthening nails.
- To analyze pain trends during the distraction phase in a large cohort.
Main Methods:
- 168 patients undergoing tibial or femoral DO with five different LN models were studied.
- Standardized medical protocols were followed for pain management.
- Daily pain was recorded using the Numerical Rating Scale (NRS) during the distraction period.
Main Results:
- The average NRS pain score decreased by 36.3% from 2.84 on postoperative day 1 to 1.81 after 62 days.
- A significant portion of the pain reduction (23.6%) occurred within the first thirty days.
- No specific influence factors (LN model, bone type, approach, side, age, gender) were identified as affecting pain levels.
Conclusions:
- Pain during the distraction phase of DO with LN is generally low.
- Pain levels demonstrate a consistent decreasing trend throughout the distraction period.
- Pain is effectively managed with non-opioid analgesics, suggesting good patient tolerance.
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