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Updated: Sep 25, 2025
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Pain levels during distraction osteogenesis with lengthening nails in 168 cases
Nikolaus Degen1,2, N de Almeida Lopes3,4, F Wolf3,4
1Workgroup 3D-Surgery, LMU Munich, Campus Innenstadt: Ziemssenstr. 1, 80336, Munich, Germany. ndegen@med.lmu.de.
Purpose:
To firstly examine the pain levels during distraction osteogenesis (DO) with lengthening nails (LN) in a large sample.
Methods:
A total of 168 cases underwent DO of the tibia or femur with five different models of LN. Under a standardized medical regime, daily pain levels were noted as nominal rating scale (NRS) score (0-10) during the distraction phase. NRS scores and several potential influence factors (LN model, bone, approach, side, age, gender) were evaluated.
Results:
The mean distraction length was 39.1 ± 14.4 mm. The average NRS score decreased from postoperative day 1 with 2.84 nonlinearly by 1.03 points (36.3%) over the course of 62 days to an average score of 1.81. The mean decrease during the first thirty days was 0.67(23.6%). Subgroup analysis did not reveal any influence factors.
Conclusion:
Pain levels during the distraction phase are overall low, continuously decreasing, and well manageable with mostly non-opioid analgesics.
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