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Updated: Sep 25, 2025

Experimental Metastasis Assay
Published on: August 24, 2010
The Genetic Evolution of Metastasis
Aljosja Rogiers1,2, Irene Lobon1, Lavinia Spain1,3,4,5
1Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Abstract:
Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.
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