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Related Concept Videos

Clinical Trials01:16

Clinical Trials

9.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.4K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.4K
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

643
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
643
Preclinical Development: Overview01:28

Preclinical Development: Overview

4.9K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.9K
Hazard Ratio01:12

Hazard Ratio

274
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
274
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

185
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
185

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Related Experiment Video

Updated: Sep 25, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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Clinical trial management: a profession in crisis?

E J Mitchell1, K Goodman2, N Wakefield3

  • 1Nottingham Clinical Trials Unit, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. eleanor.mitchell@nottingham.ac.uk.

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|April 28, 2022
PubMed
Summary

The UK faces a critical shortage of clinical trial managers, exacerbated by the COVID-19 pandemic, impacting research delivery. Addressing recruitment and retention is vital for the future of UK clinical research.

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Area of Science:

  • Clinical Research Management
  • Healthcare Workforce Studies
  • Public Health Policy

Background:

  • The UK is experiencing a significant recruitment and retention crisis for clinical trial managers.
  • This shortage is attributed to complex factors, likely intensified by the COVID-19 pandemic.
  • Academic clinical trial units face difficulties filling vacant positions for this specialized role.

Discussion:

  • Multiple factors are negatively impacting the retention of highly skilled clinical trial managers.
  • The current crisis poses substantial challenges to achieving the goals of the Department of Health and Social Care's Future of UK Clinical Research Delivery implementation plan.
  • This article, authored by a UK Trial Managers network, explores these issues and potential solutions.

Key Insights:

  • A critical shortage of clinical trial managers exists in the UK.
  • The COVID-19 pandemic has likely exacerbated pre-existing recruitment and retention challenges.
  • Failure to address this workforce issue threatens the successful delivery of UK clinical research.

Outlook:

  • Urgent national stakeholder action is required to address the clinical trial manager shortage.
  • Strategies must focus on both recruitment into and retention within this vital profession.
  • Resolving this crisis is essential for the future success of the UK's clinical research landscape.