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Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

Daisuke Aibara1,2, Shogo Takahashi1,3, Tomoki Yagai1

  • 1Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Iscience
|April 28, 2022
PubMed
Summary

Peroxisome proliferator-activated receptor alpha (PPARA) activation drives liver cell growth by epigenetically repressing CDH1. This involves the PPARA-E2F8-UHRF1 pathway, revealing a novel mechanism for controlling hepatocyte proliferation.

Keywords:
Molecular biologyMolecular mechanism of gene regulationTranscriptomics

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