Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Curvature-Conforming Nanostructured Encapsulation for Washable and Mechanically Reliable Fiber OLEDs.

ACS applied materials & interfaces·2026

Same author

Chemical Control of Garlic Leaf Blight Through Unmanned Aerial Vehicle Based Application.

The plant pathology journal·2026

Same author

Near-Theoretical-Limit Doping of Poly(benzodifurandione) through Carbonyl-Driven Aminoalkylsilane Attachment.

Journal of the American Chemical Society·2026

Same author

Advances in light-based 3D bioprinting.

Biofabrication·2026

Same author

Adipocytes as Orchestrators of Multimodal Cancer Therapy Resistance.

Biomolecules & therapeutics·2026

Same author

MHY5456, an FXR Agonist, Ameliorates Hepatic Steatosis and Fibrosis in a Mouse Model of MASLD.

Biomolecules & therapeutics·2026

Same journal

Tailoring Drug Release Profiles From Electrospun Alginate Fibers Through Integration of Mesoporous Silica Nanoparticles.

Advanced healthcare materials·2026

Same journal

Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics.

Advanced healthcare materials·2026

Same journal

Injectable Thermosensitive Hydrogel Targeting STAT3 Reprograms Neutrophils to Amplify Anti-Tumor Immunity Post-Radiofrequency Ablation in HCC.

Advanced healthcare materials·2026

Same journal

Engineering Urchin-Shaped Copper Nanospheres for Synergistic Apoptosis and Cuproptosis via Oxidative Stress Amplification in Cancer Therapy.

Advanced healthcare materials·2026

Same journal

Blue Light-Mediated Nitric Oxide-Releasing Formulation for the Multimodal Treatment of Acne Vulgaris.

Advanced healthcare materials·2026

Same journal

Extracellular Vesicles in Wearable Delivery Systems for Cosmeceutical Applications.

Advanced healthcare materials·2026

See all related articles

Search research articles

Home
Chamber-specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes To Drive Engineered Heart Tissue Development And Function.

Home
Chamber-specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes To Drive Engineered Heart Tissue Development And Function.

Related Experiment Video

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Published on: March 21, 2019

Chamber-Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive

Dong Gyu Hwang¹, Myungji Kim², Hwanyong Choi²

¹Center for 3D Organ Printing and Stem Cells, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.

Advanced Healthcare Materials

|May 6, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

3D bioprinting chamber‐specific dECM decellularized extracellular matrix engineered heart tissue

More Related Videos

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Related Experiment Videos

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Published on: March 21, 2019

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

Decellularized extracellular matrix (dECM) from different heart chambers uniquely influences cardiomyocyte maturation. Understanding these chamber-specific cues is key for developing advanced engineered heart tissues (EHTs).

Area of Science:

Biomaterials Science
Cardiovascular Research
Stem Cell Biology

Background:

Decellularized extracellular matrix (dECM) retains native tissue cues for biomaterial applications.
Regional variations within an organ's ECM are poorly understood but crucial for tissue engineering.
Induced pluripotent stem cell-derived cardiomyocyte (CM) subtypes offer potential for engineered heart tissues (EHTs).

Purpose of the Study:

To investigate the chamber-specific effects of ventricular (vtdECM) and atrial (atdECM) dECMs on engineered heart tissue (EHT) formation.
To compare the influence of vtdECM and atdECM on the maturation and function of distinct cardiomyocyte (CM) subtypes.
To explore the impact of encapsulation timing on CM maturation within different dECM environments.

Main Methods:

Proteomic analysis to characterize vtdECM and atdECM composition.
Co-culture of induced pluripotent stem cell-derived CM subtypes with chamber-specific dECMs.
Assessment of CM maturation, function, and gene expression.
Evaluation of the effects of early versus late CM encapsulation.

Main Results:

Proteomic analysis revealed distinct protein profiles for vtdECM and atdECM.
Ventricular CMs showed enhanced maturation and function in vtdECM.
Atrial CMs exhibited limited responsiveness to ECM composition, despite transcriptomic changes.
Encapsulation timing modulated structural maturation (early) and calcium handling (late).

Conclusions:

Chamber-specific dECM composition significantly impacts subtype-specific cardiomyocyte maturation and function in EHTs.
Developmental timing of encapsulation acts synergistically with ECM cues to regulate CM development.
These findings provide a foundation for designing more physiologically accurate engineered heart tissues.